What question did this study set out to answer?

To examine how glutathione and its associated enzyme network function in an integrated manner to defend cells against oxidative stress and chemical toxicity.

January 1, 1999Free Radical Research

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress

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Authors

JHJohn D. HayesPacific University Oregon LMLesley I. McLellanDefence Science and Technology Laboratory

Discussion

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Implication

Scientific review uncovers coordinated antioxidant defense mechanisms mediated by glutathione in cells, highlighting clinical implications for chemoprevention and drug resistance.

Key Points

To examine how glutathione and its associated enzyme network function in an integrated manner to defend cells against oxidative stress and chemical toxicity.
Reviewed cellular mechanisms involving glutathione synthesis, peroxidase reduction, transferase conjugation, and export pump functions.
Evaluated transcriptional control mechanisms driven by the antioxidant responsive element (ARE) and basic leucine zipper transcription factors.
Glutathione and related enzymes act as an interconnected system that scavenges free radicals, reduces toxic peroxides, and conjugates reactive electrophiles.
Transcriptional activation via the antioxidant responsive element (ARE), mediated by Nrf and small Maf proteins, coordinates the cellular stress response to reactive oxygen species.
ARE-regulated gene expression underlies enhanced protection mediated by chemopreventive agents while also driving acquired chemotherapy resistance in tumor cells.

Cite This Study

Hayes et al. (1999) studied this question.

synapsesocial.com/papers/69daa1ba85037e71b268433a https://doi.org/10.1080/10715769900300851

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Implication

Scientific review uncovers coordinated antioxidant defense mechanisms mediated by glutathione in cells, highlighting clinical implications for chemoprevention and drug resistance.

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress

Discussion

Member takes

Implication

Key Points

Cite This Study

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress

Discussion

Member takes

Implication

Key Points

Cite This Study

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