November 1, 1994Endocrinology

Expression of insulin-like growth factor-I (IGF-I) and IGF-binding proteins during adipogenesis.

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Population

Primary mouse preadipocytes and the 3T3-L1 preadipocyte cell line

Comparison

Stimulation to differentiate with IGF-I vs Undifferentiated state (before differentiation)

Design

Preclinical

Authors

CBCharlotte M. BoneyBaystate Medical Center BMBillie M. Moats‐StaatsNorthwestern University ASAlan D. StilesUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Murine adipocyte IGFBP patterns, including larger IGFBP-2, remain hypothesis-generating; leaves open any role in human metabolic disease.

Structured PICO

Population

Primary mouse preadipocytes and the 3T3-L1 preadipocyte cell line

Intervention

Stimulation to differentiate with IGF-I

Comparator

Undifferentiated state (before differentiation)

Outcome

Expression of IGF-I and IGF-binding proteins (IGFBPs) before and during differentiationsurrogate

The presence of a larger isoform of IGFBP-2 and a potentially novel IGFBP during IGF-I-stimulated adipogenesis suggests these proteins may modulate IGF-I action in adipocyte differentiation.

Cite This Study

Boney et al. (1994) studied this question.

synapsesocial.com/papers/69daa1f4615cc0c8eaa3c2dc https://doi.org/10.1210/endo.135.5.7525256

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