Autoimmune extraintestinal manifestations of Helicobacter pylori infection: A bundle of conflicts

It has been well-known that several microorganismsthat have an effect on particular areas of the body might additionally havesystemic sequelae. In the last ten years, various studies have been performedon the relationship between Helicobacterpylori infection and a variety of extra digestive illnesses including immunological,hematological, neurological disorders and different pathologies. It has beenrecommended that complicated interactions between bacterial and host geneticfactors, as well as environmental factors, play considerable roles indetermining different clinical outcomes. Although, there are conflicting and controversy data in some diseases,in the light of literature, it is currently accepted; that the presence orabsence of H. pylori infection mightinfluence the chance of developing of many autoimmune diseases. Treatment of H. pylori infection has been reported tobe effective in some diseases like Schoenlein-Henoch purpura, ITP, psoriasisand chronic autoimmune urticaria. This review focuses the possible role of H. pylori infections in various autoimmunediseases taking into account the recent literature.