Why the study?
The functions of YAP and TAZ in macrophage polarization and post-myocardial infarction inflammation, remodeling, and healing are not well established.
Does genetic deletion of YAP/TAZ in macrophages improve infarct healing and cardiac function after myocardial infarction?
Does genetic deletion of YAP/TAZ in macrophages improve infarct healing and cardiac function after myocardial infarction?
YAP/TAZ deficiency in macrophages promotes a reparative phenotype, reducing fibrosis and improving cardiac function after myocardial infarction.
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Hypothesis-generating for macrophage YAP/TAZ targeting post-MI; leaves open translation to human therapeutics.
Mia et al. (2020) studied this question.
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