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July 4, 2006Горный информационно-аналитический бюллетень (научно-технический журнал)

Ex Vivo Activated Human Macrophages Improve Healing, Remodeling, and Function of the Infarcted Heart

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Why the study?

Does injection of ex vivo activated human macrophages improve healing, remodeling, and function in a rat model of myocardial infarction?

Population

Rats with myocardial infarction induced by coronary artery ligation (n=17)

Comparison

Human activated macrophage suspension injected… vs Saline injection

Design

Preclinical

Follow-up

5 weeks

Authors

JLJonathan LeorHeart Failure & TransplantLRLiat RozenBen-Gurion University of the NegevAZAdi Zuloff‐ShaniWix.com (Israel)

Discussion

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Implication

Activated macrophage therapy shows promise in rat MI models; leaves open translation to human remodeling trials.

Structured PICO

Does injection of ex vivo activated human macrophages improve healing, remodeling, and function in a rat model of myocardial infarction?

P
Population
Rats with myocardial infarction induced by coronary artery ligation (n=17)
I
Intervention
Human activated macrophage suspension (AMS) (approximately 4 x 10^5 cells) injected into the ischemic myocardium immediately after coronary artery ligation
C
Comparator
Saline injection
O
Outcome
Scar vessel density, myofibroblast accumulation, recruitment of resident monocytes and macrophages, scar thickening, left ventricular (LV) diastolic dilatation, and LV fractional shortening at 5 weekssurrogate

Injection of ex vivo activated human macrophages into the infarcted myocardium of rats accelerates vascularization and improves cardiac remodeling and function.

Cite This Study

Leor et al. (2006) studied this question.

synapsesocial.com/papers/6a7025ad439bab0cabc30a43https://doi.org/10.1161/circulationaha.105.000331
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