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Biochemical study reveals that cobalt amine complexes and Ru265 reversibly block the mitochondrial calcium uniporter, highlighting the DIME motif as a central target for ion channel inhibition.
We report our investigation into the MCU-inhibitory activity of Co3+ complexes in comparison to Ru265. These compounds reversibly inhibit the MCU with nanomolar potency. Mutagenesis studies and molecular docking simulations suggest that the complexes operate through interactions with the DIME motif of the MCU pore.
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Woods et al. (2021) studied this question.
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