Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress, predicts all-cause and cardiovascular mortality in the general population

Shanjie Wang; Yige Liu; Jinxin Liu; Wei Tian; Xiaoyuan Zhang; Hengxuan Cai; Shaohong Fang; Bo Yu

doi:10.1016/j.redox.2020.101741

September 30, 2020Redox BiologyOpen Access

Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress, predicts all-cause and cardiovascular mortality in the general population

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Key Points

To assess whether circulating mitochondria-derived methylmalonic acid serves as a biomarker of mitochondrial dysfunction to predict all-cause and cardiovascular mortality in the general population.
Measured circulating levels of mitochondria-derived methylmalonic acid in an adult general population cohort.
Evaluated the association between methylmalonic acid concentrations and long-term outcomes, including cardiovascular disease and all-cause mortality.
Circulating levels of methylmalonic acid demonstrated a strong positive association with increased all-cause mortality in adults.
Elevated methylmalonic acid independently predicted higher cardiovascular mortality, supporting its role as a surrogate biomarker of poor clinical prognosis.

Implication

Observational study reveals increased all-cause and cardiovascular mortality in adults with elevated methylmalonic acid, highlighting its surrogate biomarker role.

Abstract

Circulating level of mitochondrial-derived MMA is strongly associated with elevated all-cause and cardiovascular mortality. Our results support MMA as a surrogate biomarker of mitochondrial dysfunction to predict poor prognosis in adults. The biological mechanisms under cardiovascular disease warrant further investigation.

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Cite This Study

Wang et al. (2020) studied this question.

synapsesocial.com/papers/69daa59d8988aeabbe687243 https://doi.org/10.1016/j.redox.2020.101741

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Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress, predicts all-cause and cardiovascular mortality in the general population

Key Points

Implication

Abstract

Discussion

Cite This Study

Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress, predicts all-cause and cardiovascular mortality in the general population

Key Points

Implication

Abstract

Discussion

Cite This Study

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