October 27, 1995Science

Central Command Neurons of the Sympathetic Nervous System: Basis of the Fight-or-Flight Response

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Population

Preclinical model (specific organism not stated in abstract)

Design

Preclinical

Authors

AJArthur S.P JansenWashington University in St. Louis XNXay Van NguyenWashington University in St. Louis VKVladimir KarpitskiyWashington University in St. Louis

Discussion

Member takes

Implication

No immediate clinical application; leaves open whether these neurons represent therapeutic targets in human autonomic cardiovascular disease.

Structured PICO

Population

Preclinical model (specific organism not stated in abstract)

Intervention

Double-virus transneuronal labeling technique

Outcome

Identification of central autonomic neurons providing dual input to sympathetic preganglionic neurons regulating cardiac and adrenal medullary functions

Demonstrates the anatomical basis for the fight-or-flight response via central autonomic neurons in the hypothalamus and brainstem that simultaneously regulate cardiac and adrenal sympathetic outflows.

Cite This Study

Jansen et al. (1995) studied this question.

synapsesocial.com/papers/69daa59da6045d71bfa3d6e6 https://doi.org/10.1126/science.270.5236.644

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Implication

No immediate clinical application; leaves open whether these neurons represent therapeutic targets in human autonomic cardiovascular disease.

Central Command Neurons of the Sympathetic Nervous System: Basis of the Fight-or-Flight Response

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Central Command Neurons of the Sympathetic Nervous System: Basis of the Fight-or-Flight Response

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider