Instillation of particulate matter 2.5 induced acute lung injury and attenuated the injury recovery in ACE2 knockout mice

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Population

Wild type (C57BL/6, WT) and ACE2 gene knockout (ACE2 KO) mice

Comparison

PM2.5 exposure through intratracheal… vs Comparison between WT and ACE2 KO mice exposed…

Design

Preclinical

Follow-up

Up to 5 days postinstillation

Authors

Discussion

ACE2 may aid murine ALI recovery after PM2.5; hypothesis-generating for human relevance and requires clinical validation.

Population

Wild type (C57BL/6, WT) and ACE2 gene knockout (ACE2 KO) mice

Intervention

PM2.5 exposure through intratracheal instillation once a day for 3 days (6.25 mg/kg/day)

Comparator

Comparison between WT and ACE2 KO mice exposed to PM2.5

Outcome

Acute lung injury severity and recovery (measured by resting respiratory rate, inflammatory cytokines, ACE, and MMPs)surrogate

ACE2 plays a protective role in the recovery from PM2.5-induced acute lung injury in mice.

Lin et al. (2018) studied this question.

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