Review demonstrates the catalytic and regenerative properties of ceria nanoparticles in orthopedics, highlighting their value in bone tissue engineering.
The ongoing biomedical nanotechnology has intrigued increasingly intense interests in cerium oxide nanoparticles, ceria nanoparticles or nano-ceria (CeO₂-NPs). Their remarkable vacancy-oxygen defect (VO) facilitates the redox process and catalytic activity. The verification has illustrated that CeO₂-NPs, a nanozyme based on inorganic nanoparticles, can achieve the anti-inflammatory effect, cancer resistance, and angiogenesis. Also, they can well complement other materials in tissue engineering (TE). Pertinent to the properties of CeO₂-NPs and the pragmatic biosynthesis methods, this review will emphasize the recent application of CeO₂-NPs to orthopedic biomedicine, in particular, the bone tissue engineering (BTE). The presentation, assessment, and outlook of the orthopedic potential and shortcomings of CeO₂-NPs in this review expect to provide reference values for the future research and development of therapeutic agents based on CeO₂-NPs.
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Li et al. (2020) studied this question.
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