Does a Genomic Risk Score (GRS) based on a large number of SNPs improve coronary heart disease risk prediction compared to traditional clinical risk scores?
A genomic risk score utilizing numerous SNPs enhances coronary heart disease risk prediction beyond traditional clinical risk scores.
A GRS based on a large number of SNPs improves CHD risk prediction and encodes different trajectories of lifetime risk not captured by traditional clinical risk scores.
Abraham et al. (2016) studied this question.