Genetic Risk Prediction and a 2-Stage Risk Screening Strategy for Coronary Heart Disease
Key result
Adding a 28-variant genetic risk score to conventional risk factors improved risk discrimination for incident CHD (C-index 0.856 vs 0.851; P=0.0002).
Why the study?
Does adding a multilocus genetic risk score to conventional risk factors improve risk prediction for incident coronary heart disease in a general population?
Population
24,124 participants in 4 Finnish population-based, prospective cohorts (recruitment years 1992-2002)
Comparison
Multilocus genetic risk score added to… vs Conventional risk factors and family history alone
Design
Cohort
Follow-up
median 12 years (IQR 8.75-15.25 years)
Authors
Discussion
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Implication
May modestly refine CHD risk stratification in cohorts; leaves open effects on decisions and outcomes.
Study Design
Type
Cohort (n=24,124)
Multicenter
Yes
Structured PICO
Does adding a multilocus genetic risk score to conventional risk factors improve risk prediction for incident coronary heart disease in a general population?
P
Population
24,124 participants in 4 Finnish population-based, prospective cohorts (recruitment years 1992-2002)
I
Intervention
Multilocus genetic risk score (28 genetic variants) added to conventional risk factors and family history
C
Comparator
Conventional risk factors and family history alone
O
Outcome
Incident coronary heart disease (CHD) eventshard clinical
Main Result
Absolute Event Rate: 0.856% vs 0.851%
p-value: p=0.0002
Adding a 28-variant genetic risk score to conventional risk factors modestly improves CHD risk discrimination and can reclassify intermediate-risk individuals to guide statin therapy.
Cite This Study
Tikkanen et al. (2013) conducted a cohort in Coronary Heart Disease (n=24,124). Multilocus genetic risk score (28 genetic variants) vs. Conventional risk factors and family history was evaluated on Risk discrimination of CHD (C-index) (p=0.0002). Adding a 28-variant genetic risk score to conventional risk factors improved risk discrimination for incident CHD (C-index 0.856 vs 0.851; P=0.0002).