What question did this study set out to answer?

To review the intracellular pathways governing exosome formation and secretion, while delineating their physiological roles in multicellular organisms.

May 1, 2002TrafficOpen Access

The Biogenesis and Functions of Exosomes

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Authors

WSWillem StoorvogelUtrecht University MKMonique J. KleijmeerUtrecht University HGHans J. GeuzeDartmouth College

Discussion

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Overview

Review reveals mechanisms of exosome biogenesis and secretion in multicellular systems, highlighting their critical roles in intercellular communication and immune regulation.

Key Points

To review the intracellular pathways governing exosome formation and secretion, while delineating their physiological roles in multicellular organisms.
Evaluated the intracellular generation of 40–100 nm vesicles via inward budding of the endosomal multivesicular body membrane.
Examined the selective sequestration of specific proteins and lipids into exosomes prior to exocytic fusion with the plasma membrane.
Exosomes are confirmed as 40–100 nm vesicles released into the extracellular space when multivesicular bodies fuse with the plasma membrane.
The inward budding process enriches exosomes with distinct sets of cellular proteins and lipids tailored for specialized extracellular tasks.
Exosome-mediated transport plays a central physiological role in cell-to-cell communication, regulating immune responses and supporting tissue development.

Cite This Study

Stoorvogel et al. (2002) studied this question.

synapsesocial.com/papers/69daaab2a6045d71bfa3daec https://doi.org/10.1034/j.1600-0854.2002.30502.x

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May 1, 2002TrafficOpen Access

The Biogenesis and Functions of Exosomes

View Full Paper

Ask AI

Bookmark

Authors

WSWillem StoorvogelUtrecht University MKMonique J. KleijmeerUtrecht University HGHans J. GeuzeDartmouth College

Discussion

Member takes

Overview

Review reveals mechanisms of exosome biogenesis and secretion in multicellular systems, highlighting their critical roles in intercellular communication and immune regulation.

Key Points

To review the intracellular pathways governing exosome formation and secretion, while delineating their physiological roles in multicellular organisms.
Evaluated the intracellular generation of 40–100 nm vesicles via inward budding of the endosomal multivesicular body membrane.
Examined the selective sequestration of specific proteins and lipids into exosomes prior to exocytic fusion with the plasma membrane.
Exosomes are confirmed as 40–100 nm vesicles released into the extracellular space when multivesicular bodies fuse with the plasma membrane.
The inward budding process enriches exosomes with distinct sets of cellular proteins and lipids tailored for specialized extracellular tasks.
Exosome-mediated transport plays a central physiological role in cell-to-cell communication, regulating immune responses and supporting tissue development.

Cite This Study

Stoorvogel et al. (2002) studied this question.

synapsesocial.com/papers/69daaab2a6045d71bfa3daec https://doi.org/10.1034/j.1600-0854.2002.30502.x

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