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June 20, 2018Lara D. VeekenOpen Access

Tofacitinib for refractory interstitial lung diseases in anti-melanoma differentiation-associated 5 gene antibody-positive dermatomyositis

Kazuhiro Kurasawa Satoko Arai Y. Namiki Ayae Tanaka Yuta Takamura Takayoshi Owada Masafumi Arima Reika Maezawa

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Abstract

Combination therapy with TOF might have the potential to control refractory anti-MDA5 Ab+ DM-ILD.

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Kurasawa et al. (2018) studied this question.

synapsesocial.com/papers/69daab723bc1ef72256848dd https://doi.org/10.1093/rheumatology/key188

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Autoantibodies to a 140‐kd polypeptide, CADM‐140, in Japanese patients with clinically amyopathic dermatomyositisOriginal Research · 2005 · 747 citations
2Clinical significance and new detection system of autoantibodies in myositis with interstitial lung diseasereview · 2016 · 118 citations
3The diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with DMCohort Study · 2012 · 314 citations
4Cytokine profiles in polymyositis and dermatomyositis complicated by rapidly progressive or chronic interstitial lung diseasePrognostic Study · 2014 · 185 citations
5Anti-MDA5 antibody, ferritin and IL-18 are useful for the evaluation of response to treatment in interstitial lung disease with anti-MDA5 antibody-positive dermatomyositisPrognostic Study · 2012 · 339 citations

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