Comparison Between Drug-Coated Balloon and Stents in Large De Novo Coronary Artery Disease: A Systematic Review and Meta-Analysis of RCT Data

Figures

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  Fig. 1. Study search diagram. Summary of how the systematic search was conducted and eligible studies were identified

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  Fig. 2. Meta-analysis of major cardiovascular adverse events in patients with large vessel de novo coronary artery disease. The forest plot illustrates the results of the main analysis: DCB compared with stents produced a 52% RR reduction. DCB: drug-coated balloons, CI: confidence interval, RR: risk ratio

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  Fig. 3. Subgroup analysis of MACE according to patient status and type of stents. DCB: drug-coated balloons, CCS: chronic coronary syndrome; ACS: acute coronary syndrome; BMS: bare-metal stent, DES: drug-eluting stent; CI: confidence interval, RR: risk ratio

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  Fig. 4. Trial sequential analysis of the included studies. A one-sided graph is plotted by TSA, where the dotted lines represent the conventional significance boundaries, the blue line indicates the cumulative Z-score, and the red lines shows the trial sequential monitoring boundary. TSA, Trial sequential analysis; RIS, Required information size

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  Fig. 5. Summary plots for the clinical outcomes. DCB: drug-coated balloon, MI: myocardial infarction, CD: cardiovascular death, TLR: target lesion revascularization, CI: confidence interval, RR: risk ratio

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  Fig. 6. Summary plots for the angiographic outcomes. DCB: drug-coated balloons, MLD: minimal lumen diameter, LLL: late lume loss, CI: confidence interval, RR: risk ratio