Does shortening door-to-balloon (D2B) or onset-to-door (O2D) time reduce 1-year all-cause mortality in patients with STEMI undergoing primary percutaneous coronary intervention?
Further reducing door-to-balloon time below the currently recommended 90 minutes yields continuous and significant survival benefits in STEMI patients undergoing primary PCI.
Background In patients with ST-segment-elevation myocardial infarction, timely reperfusion therapy with door-to-balloon (D2B) time 90 minutes (adjusted hazard ratio, 0.30; 95% CI , 0.19-0.42; P<0.001). Every reduction of D2B time by 30 minutes showed continuous reduction of 1-year mortality (90 to 60 minutes: absolute risk reduction, 2.4%; number needed to treat, 41.9; 60 to 30 minutes: absolute risk reduction, 2.0%; number needed to treat, 49.2). Conclusions Shortening D2B time was significantly associated with survival benefit, and the survival benefit of shortening D2B time was consistently observed, even <60 to 90 minutes.
Park et al. (Wed,) studied this question.