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May 19, 2021BMJ453 citationsOpen Access

Risk of clinical sequelae after the acute phase of SARS-CoV-2 infection: retrospective cohort study

SDSarah E. DaughertyYGYinglong GuoKHKevin Heath

Key Points

  • To determine the excess risk and types of new clinical sequelae that develop after the acute phase of SARS-CoV-2 infection.
  • Retrospective cohort study evaluating individuals post-acute SARS-CoV-2 infection compared with cohorts recovering from other viral illnesses.
  • SARS-CoV-2 infection was associated with an excess risk of incident clinical sequelae, including specific conditions rarely observed after other viral respiratory illnesses.
  • The greatest excess risk occurred among older individuals, patients with pre-existing comorbidities, and those hospitalized for acute COVID-19.
  • Younger adults (aged ≤50 years), non-hospitalized individuals, and those without prior health conditions also exhibited a significantly elevated risk of developing new post-acute sequelae.

Abstract

The results indicate the excess risk of developing new clinical sequelae after the acute phase of SARS-CoV-2 infection, including specific types of sequelae less commonly seen in other viral illnesses. Although individuals who were older, had pre-existing conditions, and were admitted to hospital because of covid-19 were at greatest excess risk, younger adults (aged ≤50), those with no pre-existing conditions, or those not admitted to hospital for covid-19 also had an increased risk of developing new clinical sequelae. The greater risk for incident sequelae after the acute phase of SARS-CoV-2 infection is relevant for healthcare planning.

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Cite This Study

Daugherty et al. (2021) studied this question.

synapsesocial.com/papers/69dab08e37b5141e3ba3c074https://doi.org/10.1136/bmj.n1098
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