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November 10, 2025Journal of Clinical MedicineOpen Access

Risk of Sequelae Following COVID-19 Infection: A Nationwide Study Focusing on Risk Factors and Long-Term Impacts

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Authors

SKSimon KjeldsenJNJan NielsenBNBente Mertz Nørgård

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Overview

Cohort study reveals high prevalence of sequelae in older adults with comorbidities, suggesting need for monitoring.

Key Points

  • This study investigates the prevalence, risk factors, and long-term impacts of COVID-19 sequelae in individuals over 40.
  • Population-based cohort study using Denmark’s healthcare databases
  • Included 1,034,093 individuals over 40 years with confirmed COVID-19
  • Participants grouped by age: 40–59 and 60+ to compare sequelae risk
  • 0.55% prevalence of sequelae of COVID-19 in both age groups
  • Higher Charlson Comorbidity Index scores linked to increased risk of sequelae
  • Significantly elevated risks of thromboembolic events, chronic lung diseases, and infections during the two-year follow-up

Cite This Study

Kjeldsen et al. (2025) studied this question.

synapsesocial.com/papers/69253a16c0ce034ddc356c14https://doi.org/10.3390/jcm14227950
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Also Consider

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  1. 1Risk of clinical sequelae after the acute phase of SARS-CoV-2 infection: retrospective cohort study2021 · 452 citations
  2. 2Post-infection sequelae of COVID-19 and other infectious diseases—a nationwide Danish study with 40-month follow-up2026
  3. 3Association of COVID-19 With Emergence of Comorbidities: A Hospital-Based Cohort Study2024
  4. 4Three-year outcomes of post-acute sequelae of COVID-192024 · 253 citations
  5. 5Cardiovascular Impact of COVID-19: Risk Factors and Post-Infection Sequelae in Recovered Patients - Insights from a Single-Center Study2023