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March 15, 2026Nature CommunicationsOpen Access

Post-infection sequelae of COVID-19 and other infectious diseases—a nationwide Danish study with 40-month follow-up

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Authors

CGClara Springhorn GrønkjærRCRune Haubo B ChristensenDKDaniel Kondziella

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Overview

Nationwide study shows COVID-19 and other infectious diseases similarly impact mental disorders and health outcomes.

Key Points

  • This research aims to compare post-infection sequelae of COVID-19 with those of other infectious diseases.
  • Analyzed nationwide registers of COVID-19 PCR tests, anti-infective prescriptions, and hospitalizations in Denmark.
  • Utilized Cox proportional hazards models to estimate rates of mental disorders and general medical conditions.
  • Followed participants for up to 40 months from March 2020 to June 2023.
  • Positive SARS-CoV-2 PCR tests were not linked to higher mental disorder rates compared to negative tests.
  • Hospitalized COVID-19 patients showed elevated rates of mental disorders similar to those with other severe infections.
  • General medical conditions were only elevated for infections preceding Omicron and fewer than 3 vaccination doses.

Cite This Study

Grønkjær et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff5c83145bc643d1bb47https://doi.org/10.1038/s41467-026-70351-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SARS-CoV-2 Infection and Risk of Postacute Psychiatric and Neurologic Diagnoses2024 · 5 citations
  2. 2Risk of Sequelae Following COVID-19 Infection: A Nationwide Study Focusing on Risk Factors and Long-Term Impacts2025
  3. 3Long-term effects on physical and mental health and work ability after COVID-19 versus other upper respiratory infections2026
  4. 4Incidence of post-COVID psychiatric disorders according to the periods of SARS-CoV-2 variant dominance: The LIFE study2024
  5. 5Temporal trajectories of COVID-19 symptoms in adults with 22 months follow-up in a prospective cohort study in Norway2024