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Demonstrates that src-family kinase inhibition reduces hypoxia-induced vasoconstrictive signaling in rat pulmonary arteries, indicating their central role in hypoxic pulmonary vasoconstriction.
Hypoxia activates srcFKs and triggers protein tyrosine phosphorylation in IPA. Hypoxia-mediated Rho-kinase activation, Ca(2+) sensitization, and [Ca(2+)](i) responses are depressed by srcFK inhibitors and/or siRNA knockdown, suggesting a central role of srcFKs in HPV.
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Knock et al. (2008) studied this question.
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