Key result
Hypoxia in rat intrapulmonary arteries induces a biphasic contractile response, with the first phase involving a transient rise in intracellular Ca2+ and the second phase involving PKC-independent Ca2+ sensitization.
The biphasic hypoxic vasoconstriction in rat pulmonary arteries consists of an initial PKC-dependent calcium rise and a subsequent PKC-independent calcium sensitization.
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Hypoxia-induced biphasic constriction in rat IPA may involve Ca2+-independent mechanisms; leaves open translation to human HPV and clinical relevance.
Robertson et al. (1995) studied this question. Hypoxia and Ro-31-8220 vs. Prehypoxic levels / reoxygenation was evaluated on Intracellular Ca2+ ([Ca2+]i) and tension. Hypoxia in rat intrapulmonary arteries induces a biphasic contractile response, with the first phase involving a transient rise in intracellular Ca2+ and the second phase involving PKC-independent Ca2+ sensitization.
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