Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis in the Management of Intermediate-Risk Pulmonary Embolism: Primary Results of the PEERLESS Randomized Controlled Trial

Figures

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  Figure 1.. Win ratio end points and odds ratios for the win ratio components. Shown are the primary and secondary win ratio end points (A) and the odds ratios for the clinical outcome components of the win ratios (B), assessed at the sooner of discharge or 7 days after the procedure. P values for the win ratio end points are derived with a modified generalized Wilcoxon test (F-S test), and P values for clinical outcomes of the win ratio are derived from the 2-sided Fisher exact test. Odds ratios and 95% Wald CIs are calculated with large-bore mechanical thrombectomy (LBMT) as the reference. *N=275 because of 1 death. CDT indicates catheter-directed thrombolysis; and ICU, intensive care unit.

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  Figure 2.. Functional and imaging assessments at the 24-hour visit. Assessments at the 24-hour visit included the proportion of patients with a modified Medical Research Council (mMRC) dyspnea score <3 vs ≥3 (A), mean respiratory rate (B), proportion of patients New York Heart Association (NYHA) class I or II vs class III or IV (C), mean modified Borg dyspnea score at rest (D), proportion of patients with normal or mildly reduced vs moderately or severely reduced right ventricular (RV) function among those with echocardiograms at baseline and 24-hour visit (E), and mean reduction in RV/left ventricle (LV) ratio from baseline based on the same type of imaging (echocardiogram or computed tomography pulmonary angiogram) at baseline and 24-hour visit (F). P values are derived from the 2-sided Fisher exact test for categorical variables (mMRC score, NYHA classification, and RV function) and from Wilcoxon rank-sum tests with continuity correction for continuous variables (respiratory rate, modified Borg score, and reduction in RV/LV ratio). CDT indicates catheter-directed thrombolysis; and LBMT, large-bore mechanical thrombectomy.

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  Figure 3.. ICU use and length of stays. Shown is postprocedural intensive care unit (ICU) use (proportion of patients with no ICU admission, ICU admission lasting 0–24 hours, and ICU admission lasting >24 hours; A) and the mean postprocedural ICU length of stay in hours among all patients (B). ICU length of stay is measured from the end of the index procedure or the time of ICU admission, whichever is later, until the time of an order to discharge from the ICU or transfer to a standard or lower-acuity unit. Total hospital length of stay is reported by number of overnights (C); postprocedural hospital length of stay is reported in days (D). P values are derived from the 2-sided Fisher exact test for categorical variables (postprocedural ICU admission) and from Wilcoxon rank-sum tests with continuity correction for continuous variables (postprocedural ICU, postprocedural hospital, and total hospital lengths of stay). CDT indicates catheter-directed thrombolysis; and LBMT, large-bore mechanical thrombectomy.