Does alteplase in conjunction with heparin prevent clinical deterioration requiring the escalation of treatment in stable patients who have acute submassive pulmonary embolism?
Alteplase added to heparin prevents clinical deterioration requiring treatment escalation in stable patients with acute submassive pulmonary embolism.
When given in conjunction with heparin, alteplase can improve the clinical course of stable patients who have acute submassive pulmonary embolism and can prevent clinical deterioration requiring the escalation of treatment during the hospital stay.
Konstantinides et al. (2002) studied this question.