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May 29, 1969New England Journal of Medicine

Resolution Rate of Acute Pulmonary Embolism in Man

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Why the study?

What is the time course of angiographic and hemodynamic resolution of acute pulmonary embolism in patients treated with heparin or venous ligation?

Population

15 patients with definite angiographic evidence of acute pulmonary embolism involving both lungs

Design

Case_series

Follow-up

Up to several weeks

Authors

JDJames E. DalenGeneral CardiologyJBJohn S. BanasTufts UniversityHBHarold L. BrooksBrigham and Women's Hospital

Discussion

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Implication

Suggests 7-day imaging may underestimate acute PE resolution after heparin; leaves open optimal follow-up timing for prospective studies.

Structured PICO

What is the time course of angiographic and hemodynamic resolution of acute pulmonary embolism in patients treated with heparin or venous ligation?

P
Population
15 patients with definite angiographic evidence of acute pulmonary embolism involving both lungs
I
Intervention
Heparin, venous ligation, or both
O
Outcome
Resolution of pulmonary embolism assessed by angiographic and hemodynamic signssurrogate

Acute pulmonary embolism shows minimal angiographic resolution at 7 days but significant hemodynamic and angiographic improvement by 10 to 21 days following treatment.

Cite This Study

Dalen et al. (1969) studied this question.

synapsesocial.com/papers/6a75d806f56d87d9178b6bfdhttps://doi.org/10.1056/nejm196905292802202
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recovery of Pulmonary Arterial Blood Flow in Patients with Pulmonary Embolism1967 · 195 citations
  2. 2Pulmonary Angiography One to Seven Days after Experimental Pulmonary Embolism1967 · 22 citations
  3. 3Early Reduction of Pulmonary Vascular Resistance after Mitral-Valve Replacement1967 · 142 citations
  4. 4ROENTGEN TECHNIQUES IN THE DIAGNOSIS OF PULMONARY THROMBOEMBOLISM1967 · 14 citations