What question did this study set out to answer?

To update international evidence-based recommendations for the screening, initial resuscitation, and clinical management of adult patients with sepsis and septic shock.

October 14, 2021Critical Care MedicineOpen Access

Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021

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To update international evidence-based recommendations for the screening, initial resuscitation, and clinical management of adult patients with sepsis and septic shock.
Assigned clinical questions across six domains (screening, infection, hemodynamics, ventilation, additional therapies, and long-term outcomes) using the PICO framework.
Conducted systematic literature searches for evidence published before May 2019, appraising certainty with GRADE methodology and Evidence-to-Decision frameworks.
Required electronic voting thresholds of at least 75% panel participation and 80% consensus for final recommendation approval.
Issued 93 total statements, including 15 strong recommendations, 54 weak recommendations, 15 best practice statements, and 9 unrated questions.
Suggested balanced crystalloids over normal saline, peripheral vasopressor initiation to avoid central line delays, and intravenous corticosteroids for refractory septic shock.
Recommended immediate antimicrobials within 1 hour for shock or probable sepsis, while advising against intravenous vitamin C and against qSOFA as a sole screening tool.

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Implication

Clinical practice guidelines report evidence-based care updates for septic shock in hospitalized adults, highlighting revised fluid resuscitation and structured long-term recovery protocols.

Cite This Study

Evans et al. (2021) studied this question.

synapsesocial.com/papers/69dab449aae38ff6ad835f6b https://doi.org/10.1097/ccm.0000000000005357

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Implication

Clinical practice guidelines report evidence-based care updates for septic shock in hospitalized adults, highlighting revised fluid resuscitation and structured long-term recovery protocols.

Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021

Key Points

Discussion

Implication

Cite This Study

Executive Summary: Surviving Sepsis Campaign: International Guidelines for the Management of Sepsis and Septic Shock 2021

Key Points

Discussion

Implication

Cite This Study

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