Biomarker Discovery in Non–Small Cell Lung Cancer: Integrating Gene Expression Profiling, Meta-analysis, and Tissue Microarray Validation

Johan Botling; Karolina Edlund; Miriam Lohr; Birte Hellwig; Lars Holmberg; Mats Lambe; Anders Berglund; Simon Ekman; Michael Bergqvist; Fredrik Pontén; André König; Oswaldo Fernandes; Mats G. Karlsson; Gisela Helenius; Christina Karlsson; Jörg Rahnenführer; Jan G. Hengstler; Patrick Micke

doi:10.1158/1078-0432.ccr-12-1139

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Abstract

Using a novel NSCLC cohort together with a meta-analysis validation approach, we have identified a set of single genes with independent prognostic impact. One of these genes, CADM1, was further established as an immunohistochemical marker with a potential application in clinical diagnostics.

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Botling et al. (2012) studied this question.

synapsesocial.com/papers/69dab4e037b5141e3ba3c3fd https://doi.org/10.1158/1078-0432.ccr-12-1139

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Biomarker Discovery in Non–Small Cell Lung Cancer: Integrating Gene Expression Profiling, Meta-analysis, and Tissue Microarray Validation

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Biomarker Discovery in Non–Small Cell Lung Cancer: Integrating Gene Expression Profiling, Meta-analysis, and Tissue Microarray Validation

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