Why the study?
Does swim training induce hypertrophic and metabolic adaptations in mice with cardiomyocyte-specific deletion of IRS1 or IRS2 compared to wild-type controls?
Does swim training induce hypertrophic and metabolic adaptations in mice with cardiomyocyte-specific deletion of IRS1 or IRS2 compared to wild-type controls?
IRS1 and IRS2 isoforms play nonredundant and essential roles in mediating the hypertrophic and metabolic response of the heart to exercise.
Authors
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Mouse data preclude clinical translation; extends mechanistic role of IRS1/2 in exercise cardiac adaptation.
Riehle et al. (2014) studied this question.
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