June 8, 2004Circulation135 citationsOpen Access
View Full PaperAerobic Fitness Is Associated With Cardiomyocyte Contractile Capacity and Endothelial Function in Exercise Training and Detraining
Structured PICO
How does exercise training and detraining affect aerobic fitness, cardiomyocyte contractile capacity, and endothelial function?
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Intervention
Exercise training and detraining
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Outcome
Aerobic fitness, cardiomyocyte dimensions, contractile capacity, and arterial relaxationsurrogate
Exercise-induced cardiovascular adaptations are highly dynamic, with aerobic fitness gained over months being lost within weeks of detraining, likely linked to cellular changes in cardiomyocytes and arterial relaxation.
Abstract
Cardiovascular adaptation to regular exercise is highly dynamic. On detraining, most of the exercise-gained aerobic fitness acquired over 2 to 3 months is lost within 2 to 4 weeks. The close association between cardiomyocyte dimensions, contractile capacity, arterial relaxation, and aerobic fitness suggests cellular mechanisms underlying these changes.