Pregnancy-Associated Plasma Protein-A (PAPP-A) in Ewing Sarcoma: Role in Tumor Growth and Immune Evasion

Sabine Heitzeneder; Elena Sotillo; Jack F. Shern; Sivasish Sindiri; Peng Xu; Robert C. Jones; Michaël Pollak; Pernille Rimmer Noer; Julie Lorette; Ladan Fazli; Anya S. Alag; Paul Meltzer; Ching C. Lau; Cheryl A. Conover; Claus Oxvig; Poul H. Sorensen; John M. Maris; Javed Khan; Crystal L. Mackall

doi:10.1093/jnci/djy209

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Abstract

This work provides a comprehensive characterization of the surfaceome of EWS, credentials PAPP-A as a highly differentially expressed therapeutic target, and discovers a novel link between IGF-1 signaling and immune evasion in cancer, thus implicating shared mechanisms of immune evasion between EWS and the placenta.

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Heitzeneder et al. (2018) studied this question.

synapsesocial.com/papers/69dab6d778a3e0e288684122 https://doi.org/10.1093/jnci/djy209

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Pregnancy-Associated Plasma Protein-A (PAPP-A) in Ewing Sarcoma: Role in Tumor Growth and Immune Evasion

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Abstract

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Cite This Study

Pregnancy-Associated Plasma Protein-A (PAPP-A) in Ewing Sarcoma: Role in Tumor Growth and Immune Evasion

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Abstract

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Cite This Study

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