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Investigate microRNA expression alterations across major human muscular disorders to identify posttranscriptional mechanisms driving muscle degeneration and regeneration.

October 17, 2007Proceedings of the National Academy of SciencesOpen Access

Distinctive patterns of microRNA expression in primary muscular disorders

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Authors

IEIris EisenbergHadassah Medical Center AEAlal EranBoston University INIchizo NishinoHeart Failure & Transplant

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Implication

Expression profiling study reveals shared and unique microRNA dysregulation across ten human muscular disorders, highlighting posttranscriptional roles in muscle pathology and regeneration.

Key Points

Investigate microRNA expression alterations across major human muscular disorders to identify posttranscriptional mechanisms driving muscle degeneration and regeneration.
Profiled the expression of microRNAs across human muscle tissue samples from 10 distinct muscular disorders, including dystrophies, congenital myopathies, and inflammatory myopathies.
Correlated predicted microRNA target interactions with mRNA expression arrays in Duchenne muscular dystrophy and Miyoshi myopathy to assess downstream gene regulation.
Identified 185 microRNAs that were significantly up- or down-regulated across the 10 muscular disorders evaluated.
Detected five microRNAs that were consistently dysregulated across nearly all disorder samples, alongside numerous disease-specific microRNA signatures.
Demonstrated functional posttranscriptional coupling between microRNAs and predicted mRNA targets involved in secondary response pathways and muscle regeneration in Duchenne muscular dystrophy.

Cite This Study

Eisenberg et al. (2007) studied this question.

synapsesocial.com/papers/69dab6deaae38ff6ad836149 https://doi.org/10.1073/pnas.0708115104

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Implication

Expression profiling study reveals shared and unique microRNA dysregulation across ten human muscular disorders, highlighting posttranscriptional roles in muscle pathology and regeneration.

Distinctive patterns of microRNA expression in primary muscular disorders

Discussion

Member takes

Implication

Key Points

Cite This Study

Distinctive patterns of microRNA expression in primary muscular disorders

Discussion

Member takes

Implication

Key Points

Cite This Study

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