The study identifies a disrupted mitochondria-ROS-HIF-Kv pathway in Fawn Hooded Rats that triggers PAH, highlighting a potential new therapeutic target for the disease.
FHRs have a chromosome 1 abnormality that disrupts a mitochondria-ROS-HIF-Kv pathway, leading to PAH. Similar abnormalities occur in idiopathic human PAH. This study reveals an intersection between oxygen-sensing mechanisms and PAH. The mitochondria-ROS-HIF-Kv pathway offers new targets for PAH therapy.
Bonnet et al. (Wed,) studied this question.