The study identifies a disrupted mitochondria-ROS-HIF-Kv pathway in Fawn Hooded Rats that triggers PAH, highlighting a potential new therapeutic target for the disease.
Answers are grounded in this paper and cite their sources.
Does not alter practice; leaves open validation of this pathway in human pulmonary arterial hypertension.
FHRs have a chromosome 1 abnormality that disrupts a mitochondria-ROS-HIF-Kv pathway, leading to PAH. Similar abnormalities occur in idiopathic human PAH. This study reveals an intersection between oxygen-sensing mechanisms and PAH. The mitochondria-ROS-HIF-Kv pathway offers new targets for PAH therapy.
No takes yet. Share an insight, caveat, or question.
Bonnet et al. (2006) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: