February 20, 2007Hypertension

Glutamatergic Inputs in the Hypothalamic Paraventricular Nucleus Maintain Sympathetic Vasomotor Tone in Hypertension

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Why the study?

Does glutamatergic input to the paraventricular nucleus contribute to heightened sympathetic outflow in hypertension?

Population

Anesthetized spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats

Comparison

Bilateral microinjection of NMDA receptor… vs Wistar-Kyoto (WKY) normotensive control rats

Design

Preclinical

Authors

DLDe‐Pei LiSun Yat-sen University HPHui‐Lin PanJoslin Diabetes Center

Discussion

Member takes

Implication

Supports PVN glutamatergic drive in SHR sympathetic overactivity; leaves open human translation and therapeutic relevance.

Structured PICO

Does glutamatergic input to the paraventricular nucleus contribute to heightened sympathetic outflow in hypertension?

Population

Anesthetized spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats

Intervention

Bilateral microinjection of NMDA receptor antagonist (2-amino-5-phosphonopentanoic acid), non-NMDA receptor antagonist (6-cyano-7-nitroquinoxaline-2,3-dione), kynurenic acid, or gabazine into the paraventricular nucleus (PVN)

Comparator

Wistar-Kyoto (WKY) normotensive control rats

Outcome

Lumbar sympathetic nerve activity, mean arterial blood pressure, and heart ratesurrogate

Resting sympathetic vasomotor tone in spontaneously hypertensive rats is maintained by tonic glutamatergic input in the paraventricular nucleus.

Cite This Study

Li et al. (2007) studied this question.

synapsesocial.com/papers/69daba11387cf706986877b9 https://doi.org/10.1161/01.hyp.0000259666.99449.74

Topics

Hypertension management

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Glutamatergic Inputs in the Hypothalamic Paraventricular Nucleus Maintain Sympathetic Vasomotor Tone in Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Glutamatergic Inputs in the Hypothalamic Paraventricular Nucleus Maintain Sympathetic Vasomotor Tone in Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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