Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH

Tim Hendrikx; Florentina Porsch; Máté G. Kiss; Dragana Rajcic; Nikolina Papac-Miličević; Constanze Hoebinger; Laura Goederle; Anastasiya Hladik; Lisa E. Shaw; Hauke Horstmann; Sylvia Knapp; Sophia Derdak; Martin Bilban; Lena Heintz; Marcin Krawczyk; Rafael Paternostro; Michael Trauner; Matthias Farlik; Dennis Wolf; Christoph J. Binder

doi:10.1016/j.jhep.2022.06.004

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Abstract

Our study defines the origin and function of macrophages (a type of immune cell) that are present in the liver and express a specific protein called TREM2. We find that these cells have an important role in protecting against non-alcoholic steatohepatitis (a progressive form of fatty liver disease). We also show that the levels of soluble TREM2 in the blood could serve as a circulating marker of non-alcoholic fatty liver disease.

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Hendrikx et al. (2022) studied this question.

synapsesocial.com/papers/69daba544e9a02dbaa684046 https://doi.org/10.1016/j.jhep.2022.06.004

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Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH

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Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH

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