This case report adds to the rare literature associating pulmonary veno-occlusive disease with prior Hodgkin's lymphoma and its treatment with radiotherapy and chemotherapy.
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May indicate late PVOD risk in Hodgkin survivors; extends sparse case reports but leaves causal link open.
Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary hypertension, and is of unknown aetiology. It has seldom been described in association with malignant disease and cytotoxic chemotherapy, and there have been only two previous reports of an association with Hodgkin's disease [1, 2]. We report a third case which developed 14 yrs after Hodgkin's disease had been diagnosed and treated, initially with radiotherapy and subsequently with chemotherapy.
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Swift et al. (1993) studied this question.
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