Why the study?
Does carotid angiographic plaque surface morphology correlate with histological markers of plaque instability?
Does carotid angiographic plaque surface morphology correlate with histological markers of plaque instability?
Carotid angiographic plaque surface morphology is a highly sensitive marker of histological plaque instability, supporting its use in assessing plaque vulnerability.
May support angiographic identification of unstable carotid plaques; leaves open prospective validation against clinical events.
In contrast to previous studies based on macroscopic assessment, we found very strong associations between detailed histology and carotid angiographic plaque surface morphology. Plaque surface morphology on carotid angiography is a highly sensitive marker of plaque instability. Studies of the predictive value of MR- and CT-based lumen contrast plaque surface imaging are required.
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Lovett et al. (2004) studied this question.
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