Hydroamination on homogeneous and heterogeneous catalysts: Kinetic study

This kinetic analysis compares homogeneous and heterogeneous catalysts for the cyclization of 6‐aminohex‐1‐yne. The reaction was studied as a model for the direct addition of amine NH bonds to CC multiple bonds (hydroamination). Kinetic modeling showed that the metal‐catalyzed hydroamination reaction is followed by a proton‐catalyzed isomerization of the primary reaction product, 2‐methylene‐piperidine, to the thermodynamically more stable 2‐methyl‐1,2‐dehydropiperidine.