Enhanced β-adrenergic signaling and catecholamine toxicity are key mechanisms underlying Takotsubo cardiomyopathy in a pluripotent stem cell model.
Preclinical stem cell data; leaves open whether β-adrenergic modulation improves TTS outcomes in patients.
Enhanced β-adrenergic signaling and higher sensitivity to catecholamine-induced toxicity were identified as mechanisms associated with the TTS phenotype. (International Takotsubo Registry [InterTAK Registry] [InterTAK]; NCT01947621).
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Borchert et al. (2017) studied this question.
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