Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy

Structured PICO

Population

Pluripotent stem cell model of Takotsubo cardiomyopathy

Outcome

Mechanisms associated with the Takotsubo syndrome (TTS) phenotypesurrogate

Enhanced β-adrenergic signaling and catecholamine toxicity are key mechanisms underlying Takotsubo cardiomyopathy in a pluripotent stem cell model.

Abstract

Enhanced β-adrenergic signaling and higher sensitivity to catecholamine-induced toxicity were identified as mechanisms associated with the TTS phenotype. (International Takotsubo Registry InterTAK Registry InterTAK; NCT01947621).

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Cite This Study

Borchert et al. (Tue,) studied this question.

synapsesocial.com/papers/69dac0888988aeabbe687a79 https://doi.org/https://doi.org/10.1016/j.jacc.2017.06.061

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