November 4, 2025American Journal of Hypertension1 citations

Hypertension in Thoracic Aortic Dissection: A Meta-Analysis-Based Consideration in the Choice of Antihypertensive Agents

SSSohat SharmaUniversity of British Columbia JSJayant SethHeart Failure & Transplant SRSimon W RabkinUniversity of British Columbia Hospital

Structured PICO

Do beta-blockers, ACE inhibitors, or ARBs reduce MACE in patients at risk of thoracic aortic dissection?

Population

Patients at risk of thoracic aortic dissection (TAD) with hypertension

Intervention

Antihypertensive agents (Beta-blockers, ACE inhibitors, and ARBs)

Outcome

Major adverse cardiovascular events (MACE)composite

Beta-blockers remain the most effective first-line antihypertensive therapy for reducing MACE in patients at risk of thoracic aortic dissection, supported by benefits from ACE inhibitors and ARBs.

Abstract

Hypertension is strongly associated with a risk of TAD. Beta-blockers are associated with the greatest reduction in MACE and remain the most effective first-line therapy for patients at risk of TAD. ACE inhibitors and ARBs also demonstrate benefit.

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