Neuroprotective Effects of Coenzyme Q10 on Bisphenol-A-Induced Neuroinflammation, Oxidative Stress and Cerebellar Cortex Toxicity Wistar Rats

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This study evaluated the neuroprotective effects of coenzyme Q10 (CoQ10) supplementation on Bisphenol-A (BPA)-induced cerebellar cortex toxicity in Wistar rats. Thirty-six male Wistar rats (150–200 g) were divided into six groups (n=6) and fed standard diet for 28 days. Group A (control) received corn oil (10 ml/kg), while Groups B and C (CoQ10 controls) were administered CoQ10 at 10 mg/kg and 20 mg/kg orally, respectively. Group D (BPA control) received BPA at 50 mg/kg orally. Groups E and F were co-administered BPA (50 mg/kg) with CoQ10at 10 mg/kg and 20 mg/kg respectively. Weekly weight changes were recorded. At the end of the experiment, animals were sacrificed, and cerebellar tissues were either homogenised for biochemical analysis of oxidative stress markers, inflammatory markers, and antioxidant enzyme activities or processed for general histology. Results showed that exposure to BPA group D) caused significant weight loss, significant increase in malondialdehyde (MDA) levels, and significant decrease in antioxidant markers (SOD, GSH, TAC, CAT) compared to the control (p<0.05). Inflammatory markers (IL-1β and TNF-α) significantly increased in Group D. CoQ10 supplementation in Groups E and F significantly reduced antioxidant markers (SOD, GSH, TAC, CAT), MDA and inflammatory markers, and mitigated weight loss. Histological analysis showed neuronal loss in Group D, which was reversed in Groups E and F. CoQ10 supplementation protects against BPA-induced cerebellar cortex toxicity by reducing oxidative stress, inflammation, and neuronal damage, highlighting its potential as a neuroprotective agent.