Trends in excess mortality associated with atrial fibrillation over 45 years (Framingham Heart Study): community based cohort study

Figures

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  Fig 1. Temporal trends for the association between newly diagnosed atrial fibrillation and all cause mortality. Data are hazard ratios (95% confidence intervals) for the association between time varying atrial fibrillation and death (in participants with v those without atrial fibrillation). Multivariable models were adjusted for the clinical covariates listed in table 1. Linear trends across time periods were tested by meta-regression models of log hazard ratios

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  Fig 2. Adjusted survival curves for participants with atrial fibrillation and matched referents. Kaplan-Meier curves since time of diagnosis of atrial fibrillation for participants with atrial fibrillation and referents, matched on age at diagnosis of atrial fibrillation, sex, and Framingham Heart Study cohort, adjusted for clinical covariates at age of diagnosis of atrial fibrillation. The adjusted difference in the restricted mean survival time at 10 years between participants with atrial fibrillation and referents is the area between the survival curves: −2.85 years (95% confidence interval −3.21 to −2.50) in time period 1, −2.10 years (−2.35 to −1.84) in period 2, and −1.99 years (95% CI −2.26 to −1.72) in period 3 (Ptrend=0.03)