Why the study?
Do changes in cardiovascular risk factors explain the decrease in ischemic stroke incidence?
Do changes in cardiovascular risk factors explain the decrease in ischemic stroke incidence?
Reductions in systolic blood pressure and smoking prevalence are major drivers of the declining incidence of ischemic stroke.
Risk factor changes may underlie much of the ischemic stroke decline; leaves open roles for additional unmeasured determinants.
Changes in cardiovascular risk factors explained 57% of the decrease in IS incidence from 1995 to 2012. Reduction in systolic blood pressure and prevalence of smoking were the most important contributors.
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Vangen-Lønne et al. (2017) studied this question.