What question did this study set out to answer?

Summarize the cellular and molecular mechanisms that govern prostate cancer metastasis to bone and identify potential targets for future therapeutics.

May 27, 2019SHILAP Revista de lepidopterologíaOpen Access

Prostate Cancer and Bone Metastases: The Underlying Mechanisms

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Authors

SWSok Kuan WongNational University of Malaysia NMNur-Vaizura MohamadNational University of Malaysia TGTijjani Rabiu GiazeUsmanu Danfodiyo University

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Implication

Literature review outlines molecular drivers of bone metastasis in advanced prostate cancer, highlighting potential therapeutic targets within the microenvironment.

Key Points

Summarize the cellular and molecular mechanisms that govern prostate cancer metastasis to bone and identify potential targets for future therapeutics.
Narrative review synthesizing current literature on cellular crosstalk and molecular signaling involved in prostate cancer bone colonization.
Metastatic progression relies on dynamic interactions among invading prostate tumor cells, bone-forming osteoblasts, and bone-resorbing osteoclasts within the skeletal microenvironment.
Elevated parathyroid hormone-related peptide (PTHrP) upregulates RANKL to stimulate osteoclast activity, triggering bone resorption and releasing growth factors that fuel cancer cell growth.

Cite This Study

Wong et al. (2019) studied this question.

synapsesocial.com/papers/69dad19eaae38ff6ad836c23 https://doi.org/10.3390/ijms20102587

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Implication

Literature review outlines molecular drivers of bone metastasis in advanced prostate cancer, highlighting potential therapeutic targets within the microenvironment.

Prostate Cancer and Bone Metastases: The Underlying Mechanisms

Discussion

Member takes

Implication

Key Points

Cite This Study

Prostate Cancer and Bone Metastases: The Underlying Mechanisms

Discussion

Member takes

Implication

Key Points

Cite This Study

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