Inhibition of Forkhead BoxO–Specific Transcription Prevents Mechanical Ventilation–Induced Diaphragm Dysfunction

Forkhead boxO is necessary for the activation of key proteolytic systems essential for mechanical ventilation-induced diaphragm atrophy and contractile dysfunction. Collectively, these results suggest that targeting forkhead boxO transcription could be a key therapeutic target to combat ventilator-induced diaphragm dysfunction.