What question did this study set out to answer?

Review the noncanonical and apoptotic signaling pathways of TRAIL in malignant and immune cell populations, with an emphasis on natural killer cell activity and translational implications.

November 20, 2020FEBS JournalOpen Access

The multifaceted role of TRAIL signaling in cancer and immunity

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Authors

LALudmila Cardoso AlvesUniversity of Bern NCNadia CorazzaUniversity of Bern OMOlivier MicheauInserm

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Implication

Literature review uncovers dual apoptotic and nonapoptotic TRAIL signaling pathways in tumor and immune cells, highlighting challenges and opportunities for targeted cancer therapeutics.

Key Points

Review the noncanonical and apoptotic signaling pathways of TRAIL in malignant and immune cell populations, with an emphasis on natural killer cell activity and translational implications.
Synthesized molecular evidence on canonical apoptotic versus nonapoptotic TRAIL signaling pathways across transformed cancer cells and nontransformed immune cells.
Evaluated regulatory mechanisms in natural killer cells and examined experimental barriers in differentiating apoptotic from nonapoptotic TRAIL pathway outcomes.
TRAIL functions as a dual-action pathway that either induces programmed cell death or triggers noncanonical survival, proliferation, and inflammatory signaling depending on cellular context.
Technical challenges in pinpointing molecular switches between apoptotic and nonapoptotic pathways continue to impede the effective design and application of TRAIL-targeted oncologic therapies.

Cite This Study

Alves et al. (2020) studied this question.

synapsesocial.com/papers/69dad521387cf70698687d5d https://doi.org/10.1111/febs.15637

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Implication

Literature review uncovers dual apoptotic and nonapoptotic TRAIL signaling pathways in tumor and immune cells, highlighting challenges and opportunities for targeted cancer therapeutics.

The multifaceted role of TRAIL signaling in cancer and immunity

Discussion

Member takes

Implication

Key Points

Cite This Study

The multifaceted role of TRAIL signaling in cancer and immunity

Discussion

Member takes

Implication

Key Points

Cite This Study

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