Haemodynamic abnormalities used to diagnose HFpEF are linked to adverse outcomes, suggesting treatments should target central pressures and cardiac output reserve.
May aid HFpEF risk stratification; hypothesis-generating for haemodynamic-targeted interventions.
Haemodynamic abnormalities currently used for diagnosis of HFpEF are associated with increased risk for adverse events. Treatments that reduce central pressures while improving cardiac output reserve may offer greatest benefit to improve outcomes in HFpEF.
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Omote et al. (2022) studied this question.
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