Atenolol versus Losartan in Children and Young Adults with Marfan's Syndrome
Why the study?
Does losartan reduce the rate of aortic-root dilatation compared to atenolol in children and young adults with Marfan's syndrome?
Population
Children and young adults with Marfan's syndrome
Comparison
Losartan vs Atenolol
Design
RCT, randomly assigned
Follow-up
3 years
Authors
Discussion
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Member takes
Implication
Losartan offers no advantage over atenolol for aortic-root dilatation in young Marfan patients; challenges prior superiority hypotheses and supports equipoise for further trials.
Structured PICO
Does losartan reduce the rate of aortic-root dilatation compared to atenolol in children and young adults with Marfan's syndrome?
P
Population
Children and young adults with Marfan's syndrome
I
Intervention
Losartan
C
Comparator
Atenolol
O
Outcome
Rate of aortic-root dilatationsurrogate
In children and young adults with Marfan's syndrome, losartan did not significantly reduce the rate of aortic-root dilatation compared to atenolol over 3 years.
Cite This Study
Lacro et al. (2014) studied this question.