Why the study?
Does chymase inhibition improve vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats?
Does chymase inhibition improve vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats?
Chymase inhibition may prevent vascular remodeling and prolong survival in stroke-prone spontaneously hypertensive rats.
Hypothesis-generating for chymase inhibition in hypertension; prospective human studies needed before clinical adoption.
Chymase might play an important role in vascular dysfunction via augmentation both of matrix metalloproteinase-9 activity and monocyte/macrophage accumulation in SHR-SP, and its inhibition may be useful for preventing vascular remodeling and prolonging survival.
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Takai et al. (2014) studied this question.
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