Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine‐ and choline‐deficient diet

K Tashiro; Shinji Takai; Denan Jin; Hiromi Yamamoto; Koji Komeda; Michihiro Hayashi; Kazuhiko Tanaka; Nobuhiko Tanigawa; Mizuo Miyazaki

doi:10.1111/j.1872-034x.2010.00627.x

March 31, 2010Hepatology Research

Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine‐ and choline‐deficient diet

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Key Points

To determine whether pharmacological inhibition of chymase protects against the onset of nonalcoholic steatohepatitis in a diet-induced hamster model.
Hamsters were fed a methionine- and choline-deficient diet to induce nonalcoholic steatohepatitis.
Animals were administered a chymase inhibitor to investigate the role of mast cell protease activity in liver pathogenesis.
Treatment with a chymase inhibitor successfully prevented the development of nonalcoholic steatohepatitis in diet-fed hamsters.
Mast cell chymase activity was identified as a critical contributor to the progression of experimental steatohepatitis.

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Implication

Animal study demonstrates that chymase inhibition prevents nonalcoholic steatohepatitis in hamsters, suggesting mast cell proteases drive disease progression.

Abstract

These findings demonstrate that the mast cell protease chymase may play a crucial role in the development of NASH in hamsters.

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Tashiro et al. (2010) studied this question.

synapsesocial.com/papers/69dae05f00ab073a27839489 https://doi.org/10.1111/j.1872-034x.2010.00627.x

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Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine‐ and choline‐deficient diet

Key Points

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Implication

Abstract

Discussion

Cite This Study

Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine‐ and choline‐deficient diet

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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