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August 1, 2024SHILAP Revista de lepidopterologíaOpen Access

Next generation probiotics for human health: An emerging perspective

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Authors

TJTawseefa JanRNRajeshwari NegiBSBabita Sharma

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Overview

Review reveals therapeutic benefits and manufacturing hurdles of next-generation probiotics in humans, highlighting delivery systems and safety frameworks essential for commercialization.

Key Points

  • To review the therapeutic potential, manufacturing obstacles, delivery strategies, and regulatory risk assessments associated with commercializing next-generation probiotics.
  • Reviewed literature evaluating candidate gut-derived bacterial genera, including Bacteroides, Faecalibacterium, Akkermansia, and Clostridium.
  • Assessed technological constraints surrounding oxygen sensitivity, nutrient demands, and encapsulation delivery systems.
  • Examined regulatory frameworks and safety criteria comparing next-generation probiotics with traditional probiotic species.
  • Next-generation probiotics show therapeutic efficacy as biopharmaceuticals and nutraceuticals, but severe oxygen sensitivity and fastidious nutritional demands restrict viability during industrial production.
  • Unlike traditional Lactobacillus and Bifidobacterium strains, genera such as Bacteroides and Clostridium present safety ambiguities regarding potential pathogenicity and infectious risks that necessitate specialized regulatory oversight.

Cite This Study

Jan et al. (2024) studied this question.

synapsesocial.com/papers/69daee3b4a1e15904c836a2chttps://doi.org/10.1016/j.heliyon.2024.e35980
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