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Demonstrates that excess cardiovascular events in pheochromocytoma stem from tumoral catecholamine toxicity rather than blood pressure, highlighting the need for prompt diagnosis.
Pheochromocytoma patients have a clearly higher rate of cardiovascular events than patients with essential hypertension. This cannot be attributed to differences in blood pressure or other cardiovascular risk factors. The most likely explanation for the excess event rate is the prolonged exposure to the toxic effects of tumoral catecholamines. These data underpin the importance of a timely diagnosis and treatment of pheochromocytoma.
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Stolk et al. (2013) studied this question.
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